SAKe: computationally designed modular protein building blocks for macromolecular assemblies

Computationally Designed Armadillo Repeat Proteins for Modular Peptide Recognition.

Armadillo repeat proteins (ArmRPs) recognize their target peptide in extended conformation and bind, in a first approximation, two residues per repeat. Thus, they may form the basis for building a modular system, in which each repeat is complementary to a piece of the target peptide. Accordingly, preselected repeats could be assembled into specific binding proteins on demand and thereby avoid t...

Re ective Building Blocks for Modular

The formal deenition of any namespace device found in a programming language can be given in terms of transformations on a semantic environment. It is therefore worthwhile to consider the implications of incorporating environments as bona de data objects in a programming system. Because of their expressive power, environments can be easily abused. Reifying an environment can entail the capture ...

Shape-anisotropic colloids: Building blocks for complex assemblies

PDNA as building blocks for membrane-guided self-assemblies.

Different semi-synthetic PDNAs (protein-DNA complexes), which encompass a protein core engineered from the cytochrome b(5) scaffold, an embedded tuneable redox cofactor, a synthetic linker and a large oligonucleotide, were designed, synthesized and purified to homogeneity. These building blocks can be reversibly attached to Ni-DOGS [1,2-dioleoyl-sn-glycero-3-[N(5-amino-1-carboxypentyl)iminodiac...

Novel Generic Middleware Building Blocks for Dependable Modular Avionics Systems

The complexity of the satellites and launchers data system tends to increase rapidly, as well as their performance requirements. The efficiency of their development will depend on the availability and integration of standard software products (e.g. COTS) solving recurrent problems in space vehicle avionics systems. To address these problems, our objective in this project was to define a middlew...